2-Chloroadenosine CAS 146-77-0

Product Description:

Product Name: 2-Chloroadenosine CAS NO: 146-77-0

 

Synonyms:

Adenosine, 2-chloro-;

2-CADO Hydrate;

2-CADO,6-Amino-2-chloropurine riboside;

 

Chemical Physical Properties:

Appearance: White powder

Assay : Greater than or equal to 99.0 percent

Density: 2.19 g/cm3

Boiling Point: 591.8 degree at 760 mmHg

Melting Point: 162 degree

Refractive Index: -50 degree (C=0.1, H2O)

Water Solubility: Soluble in water.

Storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20 degree

Solubility: H2O: 10 mg/mL, clear, colorless

 

Safety Information:

RTECS: AU7357550

WGK Germany: 3

Safety Statements: 24/25

HS Code: 29349990

Toxicity: LD50 oral in mouse: > 100mg/kg

 

A selective A1-adenosine receptor agonist. Induces apoptosis. 2-Chloroadenosine is an adenosine analogue that is not hydrolyzed by adenosine deaminase. 2-Chloroadenosine increases the rate of dopa production in intact pheochromocytoma cells, it increases the content of cAMP in the cells, and it causes a stable activation of tyrosine hydroxylase, as measured in vitro. The action of 2-Chloroadenosine is not dependent upon extracellular Ca2 plus . In other experiments, we have found that 2-chloroadenosine increases the activity of adenylate cyclase in membrane fractions prepared from the pheochromocytoma. These data provide support for the hypothesis that 2-Chloroadenosine causes a cAMP-mediated phosphorylation of tyrosine hydroxylase in pheochromocytoma cells. Chromaffin cells and adrenergic neurons store and release adenine nuc1eotides together with catecho1amines. The adenosine formed by the hydrolysis of these nucleotides may be involved in the. physiological regulation of adenylate cyclase activity and of tyrosine hydroxylase activity. To date , however, we have no evidence for such a role of adenosine in normal chromaffin cells or in adrenergic neurons.

 

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