Acotiamide Hydrochloride Trihydrate CAS 773092-05-0

Pwodwi deskripsyon:

Non pwodwi: Acotiamide hydrochloride trihydrate CAS non: 773092-05-0

 

Synonyms:            

N-(2-(Diisopropylamino) ethyl)-2-((2-hydroxy-4,5-dimethoxybenzoyl) amine)-1, 3-thiazole-4-carboxyamide monohydrochloride trihydrate;

Unii-nmw7447A9a;

AcotiaMide hydrochloride trihydrate;

 

Chimik &PhysicalProperties:

Aparans: blan poud

Asdi: ≥99,0%

Depo Temp.: sele nan sek, 2-8 ° c

 

Nan mwa Jen 2013, ministe sante a, travay ak Byennet nan Japon apwouve acotiamide (tou refere a kom Z-338 ak YM443), pou tretman an nan postprandial fullness, anwo alonnman anbavant, ak byen bone satiation akoz dyspepsia fonksyonel (FD). Acotiamide amelyore acetylcholine lage soti nan newon anstinyik nan selektif muscarinic acetylcholine récepteurs M1, M2 opozisyon, ak inhibition nan AChE, se konsa amelyore likid dechaje ak aranjman likid. Acotiamide ajite acetylcholine-pwovoke Ca2 +-aktive cl-aktyel ak yon IC50 nan 1,8 μM nan oocytes eksprime muscarinic M1 resepte ak nan oocytes eksprime muscarinic M2 resepte, acotiamide jennen acetylcholine-pwovoke K + kouran ak yon IC50 nan 10,1 μM. Sepandan, etid nan chen konsyan, Gine-kochon likid bann misk ak asdi ak cholinesterase imen endike ke acotiamide ajite AChE ak yon What nan 610 nM sigjere ke acotiamide stimule likid motility sitou pa inhibiting AChE. Nan yon model metriz estres-pwovoke rat, acotiamide siyifikativman amelyore dechaje likid ak manje inhibition men li pa te afekte likid nomal dechaje oswa manje nan rat entak. Yon wout entetik pou acotiamide ki anplwaye pyridine hydrochloride pou oaza fann yon 2-ranplase ete méthyle ki soti nan yon 2, 4, 5-trimethoxy benzamide entemedye, kom yon etap kle, te rapote.

 

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Baj popilè: acotiamide hydrochloride trihydrate cas 773092-05-0, manifaktire, founise, faktori, achte, an aksyon

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