BLU9931 CAS 1538604-68-0

Pwodwi Deskripsyon:

Non pwodwi: BLU9931 CAS NON: 1538604-68-0

 

Sinonim:

2-Propenamide, N-[2-[6-(2,6-dichloro-3,5-dimethoxyphyphyenyl) -2-quinazolinyl]amino]-3-methylphenyl];

LM-3610;

 

Chimik & Pwopriyete fizik:

Aparans: Solid oswa poud

Assay: ≥98.0%

Dansite: 1.361±0.06 g / cm3 (Prediksyon)

PKa: 13.15±0.70 (Predi)

Endeks refraksyon: 1.677

 

BLU9931 se yon ki pisan, selektif, ak ireversible FGFR4 inibitor ak yon IC50 nan 3 NM ak yon seleksyon nan 297,184 ak 50 fwa pi wo pase sa pou FGFR1 / 2 / 3, respektivman. Nan MDA-MB-453 selil yo, BLU9931 efektivman entedi fosfo a nan FGFR44 siyal wout. Blu9931 entedi pwopagasyon an nan liy selil HCC, tankou Hep3B, Huh-7, Chimik, ak JHH-7, eksprime yon entak FGFR4 siyal konpleks ak EC50<1 μm.="" blu9931="" also="" inhibits="" proliferation="" in="" pdx-derived="" cell="" lines="" with="" an="" intact="" fgfr4="" signaling="" pathway.="" in="" mice="" loaded="" with="" fgf19-amplified="" hep3b="" liver="" tumors,="" blu9931(300mg/kg,="" p.o.)="" caused="" tumor="" degeneration="" and="" prevented="" tumor-induced="" weight="" loss.="" blu9931="" (300mg/kg,="" p.o.)="" treatment="" also="" resulted="" in="" tumor="" degeneration="" in="" chemicalbook="" loaded="" mice="" with="" fgf19-="" overexpression="" of="" pdx-derived="" lixc012="">

 

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Baj popilè: blu9931 cas 1538604-68-0, manifaktire, founise, faktori, achte, nan stock

• On: 6α-ethyl-3α, 7α-dihydroxy-24-nor-5β-cholan-23-ol CAS 1612191-86-2
• Pwochen: AZD-4635 CAS 1321514-06-0