Thailanstatin A CAS 1426953-21-0

Deskripsyon pwodwi:

Non pwodwi: Thailanstatin A CAS NO: 1426953-21-0

 

Sinonim:

(3R,5S,7R,8R)-7-{(1E,3E)-5-(2S,3S,5R,6R)-5-{(2Z,4S)-4-(acetyloxy)pent -2-enoylamino}-3,6-dimethyltetrahydro-2H-pyran-2-yl-3-methylpenta-1,3-dien-1-yl}-8-hydroxy-1,6-dioxaspiro2.5oct-5-ylacetic asid;

1,6-Dioxaspiro2.5oktan-5-aceticacid,7-(1E,3E)-5-(2S,3S,5R,6R)-5-(2Z,4S) )-4-(acetyloxy)-1-oxo-2-penten-1-ylaminotetrahydro-3,6-dimethyl-2H-pyran-2-yl-3-methyl-1,3-pentadien-1-yl-8- idroksi-, (3R,5S,7R,8R)-;

 

Pwopriyete Chimik Fizik:

Aparans: solid poud

Egzamen : Pi gran pase oswa egal a 99.0 pousan

 

Thailanstatin A, yon konpoze plon pwomèt pou dekouvèt dwòg ak efò devlopman, sòti nan Thailandensis burkholderia MSMB43. Li revele ki ba nanomolar ak subnanomolar sitotoksisite kont yon varyete liy selil kansè imen.

Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding "linker-less" ADC.

 

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Baj popilè: thailanstatin a cas 1426953-21-0, manifaktirè, founisè, faktori, achte, nan stock

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