(1S) -1-Phenyl-1,2,3,4-tetrahydroisoquinoline CAS 118864-75-8

Deskripsyon pwodwi:

Non pwodwi: (1S) -1-fenil-1,2,3,4-tetrahydroisoquinoline CAS NON: 118864-75-8

Sinonim:

(1S) -1-Phenyl-1,2,3,4-tetrahydro-isopquinoline;

Solifenacin ki gen rapò Konpoze 11;

Solifenacin Succinate interMediate F;

Chimik& Pwopriyete fizik:

Aparans: Blan solid

Egzamen: ≥99.00%

Dansite: 1.065

Pwen bouyi: 338 ℃

Pwen fizyon: 80-82 ℃

Flash Point: 167 ℃

Refractive Index: 1.589

Presyon vapè: 9.87E-05mmHg nan 25 ℃

Enfòmasyon sou sekirite:

HS Kòd: 2942000000

(S) -1-phenyl-1,2,3, 4-tetrahydroisoquinoline ka itilize pou prepare sofinacin. Solifenacin succinate, CAS No 242478-38-2, non chimik 1-azabicyclic [2.2.2] octan-8-yl - (1S) -1-phenyl-3, 4-dihydro-1H-isoquinoline-2-formate succinate , Li se yon antagonist M3 muscarinic reseptè selektif devlope pa Japon' s Astellas Konpayi. Li te premye commercialisés nan Netherlands, Almay, Wayòm Ini a ak Denmark nan 2004 ak nan Lachin nan 2009. Se konsa, lwen, li te commercialisés nan plis pase 50 peyi yo ak rejyon atravè mond lan, e li te vin yon dwòg enpòtan pou tretman an nan overactivity nan blad pipi (OAB) nan Ewòp, Etazini ak Japon. Rekòmande pa otorite miltip ak direktiv. Preparasyon li se jan sa a: (S) -1-phenyl-3, 4-dihydro-1H-isoquinoline-2-formyl klori (II) te jwenn nan kondansasyon nan (S) -1-phenyl-1,2,3, 4-tetrahydroisoquinoline (I) ak triphosgene anba kondisyon baz òganik (baz fèb). Konpoze II te chofe dirèkteman anba kataliz baz òganik pa yon sèl metòd po san separasyon. Solinacine succinate (IV) te prepare pa reyaksyon kondansasyon ak (R) -3-kinin sikloalkòl pou jwenn solinacine (III).

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Baj popilè: (1s) -1-phenyl-1,2,3,4-tetrahydroisoquinoline cas 118864-75-8, manifaktirè, founisè, faktori, achte, nan stock

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