7-Xylosyl-10-deacetyltaxol CAS 90332-63-1

Deskripsyon Product

Non pwodwi: CAS-710XIL-10-deacetyltaxol 90332-63-1

Sinonim:

Asid Benzenepropanoik, β- (benzoylamino) -α-idroksile-, (2aR, 4S, 4aS, 6R, 9S, 11S, 12S, 12aR, 12bS) -12b- (acetyloxy) -12- (benzoyloksik) -2a, 3, 4,4a, 5,6,9,10,11,12,12a, 12b-dodecahydro-6,11-dihydroxy-4a, 8,13,13-t etramethyl-5-oxo-4- (β-D- xylopyranosyloxy) -7,11-methano-1H-cyclodeca [3,4] benz [1,2-b] oxet-9-y ester, (αR, βS) -;

(2α, 3β, 5β, 7β, 10β, 13α) -4-Acetoxy-13 - {[(2R, 3S) -3- (benzoylamino) -2-idroksi-3-fenilpropanoyl] oksi] -1,10-dihydroxy -9-oxo-7- (β-D-xylopyranosyloxy) -5,20-epoxytax-11-en-2-yl benzoate;

(2α, 5β, 7β, 10β, 13α) -4-Acetoxy-13 - {[(2R, 3S) -3- (benzoylamino) -2-idroksi-3-fenilpropanoyl] oksi] -1,10-dihydroxy-9 -oxo-7- (β-D-xylopyranosyloxy) -5,20-epoxytax-11-en-2-yl benzoate;

Asid Benzènpropanoik, β- (benzoylamino) -α-idroksile-, (2aR, 4S, 4aS, 6R, 9S, 11S, 12S, 12aS, 12bS) -12b- (acetyloxy) -12- (benzoyloksik) -2a, 3, 4,4a, 5,6,9,10,11,12,12a, 12b-dodecahydro-6,11-dihydroxy-4a, 8,13,13-t etramethyl-5-oxo-4- (β-D- xylopyranosyloxy) -7,11-methano-1H-cyclodeca [3,4] benz [1,2-b] oxet-9-y estè, (αR, βS) -

10-Deacetyl-7-xylosyl paclitaxel;

Chimik & Pwopriyete fizik yo

Aparans: blan poud

Tès: ≥99.0%,

Dansite: 1.5 ± 0.1 g / cm3

Pwen bouyi: 1068,4 ± 65,0 ℃ nan 760 mmHg

Flash Point: 599.9 ± 34.3 ℃

PSA: 274.14000

LogP: 7.18

Presyon vapè: 0.0 ± 0.3 mmHg nan 25 ° C

Index of Refraction: 1.660

Soluble nan methanol, etanòl, DMSO ak lòt Solvang òganik.

Paclitaxel 10-Deacetyl-7-ksilozil se yon derive Paclitaxel ak amelyore karakteristik famasi ak pi wo solubility dlo. , ak transmisyon mikroskopi elèktron. Ekspresyon pwoteyin Pro-apoptotik Bax la te reglemante ak ekspresyon anti-apoptotik Bcl-2 ak Bcl-XL ki regle, ki mennen nan yon twoub nan pèmeyabilite manbràn mitokondriyo ak nan deklanchman nan caspase-9. Nan vire, caspase-9 aktive en kaspaz-3 ak -6, men se pa caspase-8. Bid te tou aktive pa caspase-3. Ranvèse, tretman ak yon inhibitor inisyal caspase-10 pa t 'kapab pwoteje PC-3 selil ki soti nan apoptoz 7-xylosyl-10-deacetyl-paclitaxel-deklanche. Anplis, 7-xylosyl-10-deacetylpaclitaxel pa te gen okenn efè sou ekspresyon an nan CD95 ak NF-kappaB pwoteyin, ki endike ke yo te apoptoz pwovoke nan chemen an mitokondriyo-depann nan PC-3 selil yo.

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Baj popilè: 7-xylosyl-10-deacetyltaxol cas 90332-63-1, manifaktirè, founisè, faktori, achte, nan stock

• On: Allopurinol CAS 315-30-0
• Pwochen: 10-DAT, Deacetyltaxol CAS 78432-77-6