9-ethyl-6,6-Dimethyl-8-(4-Morpholinopiperidin-1-yl) -11-oxo-5a,6,11 11a-tetrahydro-5H-benzo[b]carbazole-3-carbonitrile Hydrochoride CAS 1256589-74-8

Pwodwi Deskripsyon:

Non pwodwi:

9-ethyl-6,6-Dimethyl-8-(4-Morpholinopiperidin-1-yl) -11-oxo-5a,6,11,11 11a-tetrahydro-5H-benzo[b]carbazole-3-carbonitrile hydrochoride CAS NON: 1256589-74-8

 

Sinonim:

Alectinib hydrochoride (JAN);

UNII-P9Y773LO6J;

9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]kabazole-3-kabonitri hydrochide;

 

Chimik & Pwopriyete fizik:

Aparans: Solid

Assay: ≥99.00%

Egzak Mass: 518.244873

 

Alectinib hydrochloride, devlope pa Chugai Pharmaceutiical / Hoffman-La Roche anba non an komes Alecensa®, te apwouve nan Japon nan mwa avril 2014 pou tretman anaplastik kinaz aaplastik kinaz (ALK) fizyon-gene pozitif, enkwayab, avanse, oswa repetisyon kanse poumon ki pa ti selil (NSCLC). Konpoze a se yon tre selektif dezyem jenerasyon ALK inibite, e pandan ke alectinib kounye a rete yon konsantre nan plis devlopman nan Ewop ak peyi Etazini an, konpoze a te akode desen dwog ofelen nan Japon apre yo fin montre yon pousantaj repons objektif 93.5 nan faz II ese klinik. Anplis de sa nan bay tan repons tretman rapid nan yon majorite nan pasyan, eprev te montre yon pousantaj pwogre 76-ane-gratis pousantaj siviv. Depi apwobasyon inisyal la nan krizotinib-premye inibite a ALK endike pou tretman nan ALKrearranged NSCL - pasyan yo trete ak krizotinib gen montre amelyorasyon remakab kom konpare ak tretman ak lot metod chimyoterapitik,21 byenke rezistans dwog te montre yo dwe yon gwo efe segonde nan terapi sa a. Prelimine preklinik ak syans klinik nan alectinib te montre pwomes siyifikatif pou simonte rezistans dwog devlope ak lot inibite ALK.

 

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Baj popilè: 9-ethyl-6,6-dimethyl-8-(4-morpholinopiperidin-1-yl) -11-oxo-5a,6,11,11 tetrahydro-5h-benzo[b]carbazole-3-kabonitri hydrochloride cas 1256589-74-8, manifaktire, founise, faktori, achte, nan machandiz

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