Cevimeline Hydrochloride Hemihydrates CAS 153504-70-2

Pwodwi deskripsyon

Non pwodwi: Cevimeline hydrochloride hemihydrates CAS 153504-70-2

 

 

Synonyms:

Cevimeline hydrochloride hemihydrate;

cis-2-Methylspiro (1, 3-oxathiolane-5, 3 ') quinuclidine hydrochloride konpoze (2:2:1);

(+/-)-cis-2-Methylspiro [1, 3-oxathiolane-5, 3 '-quinuclidine] hydrochloride hemihydrate;

(+/-)-cis-2-methylspiro [1, 2-oxathiolane-5, 3 '-quinclidine] monohydrochloride;

Cevimeline Kloridrat 1/2H2o;

(+/-)-cis-2-methylspiro [1, 3-oxathiolane-5, 3 '-quinuclidine] monohydrochloride;

cevimeline hydrochloride;

(+/-)-cis-2-methylspiro [1, 3-oxathiolane-5, 3 '-quinuclidine] monohydrochloride hemihydrate;

CeviMeline hydrochloride hemihydrates;

CevimelineHCl;

 

 

Chimik & pwopriyete fizik

Aparans: blan poud

Épreuves: ≥ 99,0%

Dansite: 1.19 g/cm3

Bouyi pwen: 308.5 ° c nan 760 mmHg

Flash pwen: 140.4 ° c

 

 

Cevimeline hydrochloride hemihydrate, yon roman muscarinic récepteurs agonist, se yon kandida Dwog ki ap geri pou xerostomia nan sendwom Sjogren. IC50 vale: sib: mAChRThe jeneral pharmacol. pwopriyete Dwog sa a sou vant ak trip, rine, ak sistem repwodiksyon ak lot tisi yo te envestige nan sourit, rat, kochon, lapen, ak chen. A nan vitro metab. nan SNI-2011 te tou evalye ak rat ak chen fwa microsomes. Apre administrasyon oral, concns plasma. nan SNI-2011 rive nan Cmax nan 1 h nan tou de espes, sijere ke SNI-2011 te byen vit pedi, ak le sa a, diminye ak yon t1/2 nan 0.4-1.1 h. Byodisibilite a te 50% ak 30% nan rat ak chen, ki pa bon. gwo extracellular nan plasma te tou de S-ak N-soksid extracellular nan rat ak selman N-soksid metabolite nan chen, ki endike ke yon diferans gwo espes te obsd. nan tab la Me. SNI-2011. Diferans seks te tou obsd. nan pharmacokinetics an nan SNI-2011 nan rat, men se pa nan chen. Nan etid vitro, chem. inhibition ak yon etid pH-depandan revele ke sulfoxidn yo. ak N-oxidn. nan SNI-2011 yo te medyate pa cytochrome P 450 (CYP) ak flavin-contg. monooxygenase (FMO), a., nan tou de espes yo. Nan addn., CYP2D ak CYP3A te sitou responsab pou sulfoxidn la. nan rat fwa microsomes.

 

 

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Baj popilè: cevimeline hydrochloride hemihydrates cas 153504-70-2, manifaktire, founise, faktori, achte, nan Stock

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