EAI045 CAS 1942114-09-1

Pwodwi Deskripsyon:

Non pwodwi: EAI045 CAS NON: 1942114-09-1

 

Sinonim:

2H-Isoindole-2-acetamide, α-(5-fluoro-2-hydroxyphyphyl) -1,3-dihydro-1-okso-N-2-thiazolyl-;

2-(5-fluoro-2-hydroxyphenyl) -2-(1-oxoisindolin-2-yl) -N-(thiazol-2-yl)Acetamide;

α-(5-fluoro-2-hydroxyphenyl) -1,3-dihydro-1-okso-N-2-thiazolyl-2H-Isoindole-2-acetamide;

 

Chimik & Pwopriyete fizik:

Aparans: Crystalline solid

Assay: ≥99.0%

Dansite: 1.546±0.06 g / cm3 (Predicted)

PKa: 7.20±0.50 (prevwa)

Endeks refraksyon: 1.729

 

EAI045 se yon inibite EGFR selektif (katriyem jenerasyon). EAI045 sib chwazi dwog ki reziste EGFR mutants san yo pa afekte resepte a sovaj-kalite. EAI045 inibit L858R / T790M-mutant EGFR ak ba-nanomolar potansyel nan asochimik byochimik. Se poutet sa, li se yon dwog kandida potansyel pou tretman ki gen rapo ak kanse poumon ki pa ti selil (NSCLC). Li ta dwe remake ke EAI-045 se efektivman nan vize la EGFR C797S mitasyon, ki se rezistans nan twazyem-jenerasyon EGFR inibite ki gen ladan AZD9291 (osimertinib) ak CO-1686 (rociletinib).

 

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Baj popilè: eai045 cas 1942114-09-1, manifaktire, founise, faktori, achte, nan stock

• On: AZD9496 CAS 1639042-08-2
• Pwochen: BAR 501 Malpwòpte CAS 1632118-70-7