AZD9496 CAS 1639042-08-2

Deskripsyon pwodwi:

Non pwodwi: AZD9496 CAS NON: 1639042-08-2

Sinonim:

(E) -3- [3,5-Difluoro-4 - [(1R, 3R) -2- (2-fluoro-2-methylpropyl) -3-methyl-2,3,4,9-tetrahydro-1H- pirido [3,4-b] indol-1-il] fenil] asid Acrylic;

3- [3,5-Difluoro-4 - [(1r, 3r) -2- (2-fluor-2-methylpropyl) -2,3,4,9-tetrahydro-3-methyl-1h-pyrido [3, 4-b] indol-1-il] fenil] -2-propenoik asid;

Chimik& Pwopriyete fizik:

Aparans: kristalin solid

Egzamen: ≥99.0%

Dansite: 1.286 ± 0.06 g / cm3 (prevwa)

Bouyi Point: 541.0 ± 50.0 ℃ (prevwa)

PKa: 4.08 ± 0.10 (prevwa)

Flash Point: 281.0 ± 30.1 ℃

Presyon vapè: 0.0 ± 1.5 mmHg nan 25 ℃

Endèks Refraksyon: 1.612

AZD9496 se yon inibitè reseptè estwojèn oral ki inibit kwasans ER-pozitif ak ESR1-pote timè tete nan yon modèl timè klinik. AZD9496 ekspoze kapasite obligatwa egal a tou de ER-α ak ER-β isoforms, tou de nan seri a pmol. AZD9496 dirèkteman vize ak downregulates ERα nan vitro. AZD9496 antagonize ak desann-reglemante mutan ER nan tès vitro ak nan vivo Chemicalbook. IC50 nan AZD9496 obligatwa, desann-reglemante ak antagonik ERα yo te 0.82, 0.14 ak 0.28nM, respektivman. AZD9496 gen gwo byodisponibilite oral nan yon varyete bèt (63%, 91% ak 74% nan rat, sourit ak chen, respektivman), ak volim san ki ba ak clearance (pi wo nan sourit).

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Baj popilè: azd9496 cas 1639042-08-2, manifaktirè, founisè, faktori, achte, nan stock

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