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API ak Entèmedyè
Exatecan Mesylate CAS 169869-90-3

Exatecan Mesylate CAS 169869-90-3

CAS NON: 169869-90-3
Fòmil molekilè: C25H26FN3O7S
Pwa molekilè: 531.55300
EINECS NON: NA
MDL NON: NA

Pwodwi detay

Deskripsyon pwodwi:

Non pwodwi: Exatecan Mesylate CAS NON: 169869-90-3

 

Sinonim:

DX-8951;

Exatecan mesilate;

Exatecan (mesylate);

 

Pwopriyete Chimik Fizik:

Aparans: solid oswa likid

Egzamen : Pi gran pase oswa egal a 99.0 pousan

 

Exatecan mesylate is a semisynthetic, water{{0}}soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting the religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogs. Exatecan Mesylate (DX8951f) is a topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 ug/mL) for cancer research.

 

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