Hydroxyzine 2HCl CAS 2192-20-3

Pwodwi Deskripsyon:

Non pwodwi: Hydroxyzine 2HCl CAS NON: 2192-20-3

 

Sinonim:

2-[2-[4-[(4-chlorophenyl) -phenylmethyl]piperazin-1-yl]ethoxyol]etanol, dihydrochloride;

idroksizine hydrochloride;

Hydroxyxyzine dydrochloride;

 

Chimik & Pwopriyete fizik:

Aparans: Poud

Assay: ≥99.0%

Dansite: 1.182 g / cm3

Bouyi pwen: 499.2 ° C nan 760 mmHg

Fonn pwen: 190-192° C

Flash Pwen: 255.7 ° C

Kondisyon depo: frijent

Vapore Presyon: 8.78E-11mMHg nan 25 ° C

 

Enfomasyon sekirite:

RTECS: KK22800000

Deklarasyon Sekirite: S26

HS Kod: 2933990090

WGK Almay: 3

Deklarasyon Risk: R22; R36 / 37 / 38

Kod danje: Xn

 

H1 resepte antagonist. Anksik. Antihistaminic. Hydroxyxyzine Dihydrochloride se yon attamine H1-resepte antagonist. Sib: Istamine H1-ReceptorHydroxyxyzine inibit carbachol (10 μm) -pwovoke serotonin lage pa 34% nan 10 μM, pa 25% μM ak pa 17%0.1 μM nan tranch pipi prereglaj pou 60 min. Hydroxyzine (0.1 mM) tretman inibit pwogresyon ak severite nan EAE pa 50% ak degranasyon an nan mast selil mast pa 70% nan rat lewis ak aleji phalomit phencealomit (EAE). Hydroxyzine (500 M) siyifikativman ogmante transpo nan etoposide nan sit la serosal nan sak yo jejunal tout tan. Hydroxyzine siyifikativman redwi efflux la ak apepre 2.4 g / mL nan etoposide nan jejunum a ak ileum. Hydroxyzine (0.2 μg / mL) siyifikativman amelyore efe a nan RH123 nan limen an [3]. Hydroxyzine (500 μM) siyifikativman diminye konsantrasyon etoposid 2-pliye- pliye, kote konsantrasyon nan fiks te rive sou 0.055 μM / mL nan rat Sprague-Dawley. Hydroxyzine (12.5 mg/kg, 25 mg / kg ak 50 mg /kg i.p.p.) montre ti aktivite analjesik direk men make potansyelman selman efe a nan morfin sou vokalizasyon an apre-egzeyat ki reprezante eleman nan eleman afektif nan doule nan rat. Hydroxyzine (50 mg/kg i.p.) potansyel morfin sou tes la tail-flick, pandan yo ap Hydroxyzine (12.5 mg/kg/i.p.) diminye antinosepsyon morfin nan rat.

 

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Baj popilè: hydroxyzine 2hcl cas 2192-20-3, manifaktire, founise, faktori, achte, nan stock

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