Lifitegrast CAS 1025967-78-5

Pwodwi deskripsyon

Non pwodwi: Lifitegrast CAS NO: 1025967-78-5

 

 

Synonyms:

L-Phenylalanine, N-[[2-(6-benzofuranylcarbonyl)-5, 7-dichloro-1, 2, 3, 4-tetrahydro-6-isoquinolinyl] carbonyl]-3-(methylsulfonyl)-;

N-{[2-(1-Benzofuran-6-ylcarbonyl)-5, 7-dichloro-1, 2, 3, 4-tetrahydro-6-isoquinolinyl] carbonyl}-3-(methylsulfonyl)-L-phenylalanine;

Liegrast;

N-[[2-(6-Benzofuranylcarbonyl)-5, 7-dichloro-1, 2, 3, 4-tetrahydro-6-isoquinolinyl] carbonyl]-3-(methylsulfonyl)-L-phenylalanine;

Lifitegrast (SAR 1118);

 

 

Chimik & pwopriyete fizik

Aparans: blan off-blan solid.

Épreuves: ≥ 99,0%

 

 

Lifitegrast se yon antagonis nan lekositer antijen ki se 1, ki se itilize pou trete je sek. Lifetegras ka mare ak lekositer fonksyonel antijen-1 (LFA-1) ak anpeche obligatwa a LFA-1 nan homologous li yo ligand enteselile adezyon Molekil-1 (ICAM-1). Ekspresyon an plis nan ICAM-1 nan kone ak konjonktiv nan pasyan ki gen maladi je sek. Konbinezon an nan liv lfachemic-1 ak ICAM-1 ankouraje fomasyon an nan iminite synapses, ki mennen nan aktivasyon an nan selil T yo ak migrasyon yo a sib tisi. Nan syans vitro te montre ke lifegrant te kapab empêcher adezyon nan selil T ' nan ICAM-1 ak sekresyon nan maladies cytokines nan monosiet periferik imen. Mekanis egzak nan lifegras nan tretman nan je sek rete kle.

 

 

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Baj popilè: lifiegrast cas 1025967-78-5, manifaktire, founise, faktori, achte, nan Stock

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