MAK683 CAS 1951408-58-4

Pwodwi Deskripsyon:

Non pwodwi: MAK683 CAS NON: 1951408-58-4

 

Sinonim:

N-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl] -8-(2-methyl-3-pyridinyl) -1,2,4-triazolo[4,3-c]pirimidin-5-amine;

1,2,4-Triazolo[4,3-c]pirimidin-5-amine, N-[(5-fluoro-2,3-dihydro-4-benzofuranyl) methyl]-8-(2-methyl-3-pyridinyl);

 

Chimik & Pwopriyete fizik:

Aparans: Solid oswa poud

Assay: ≥98.0%

Dansite: 1.47±0.1 g / cm3 (Predicted)

Pka: 2.70±0.12 (Prediksyon)

Solibilite: Soluble nan DMSO.

 

EED inhibitor-1 se yon inibite EED ekstre soti nan patant US20160176882 A1, egzanp konpoze 2; gen IC50s nan 59, 89, 26 nM nan EED Alphascreen liaison, LC-MS ak ELISA adapte. MAK683 se yon inibite nan anbriyonik pwoteyin devlopman ectoderm (EED) ak aktivite potansyel antineoplastik. MAK683 mare nan domen nan EED ki reyaji ak lysine trimethylated 27 sou istwa 3 (H3K27me3), ki mennen nan yon chanjman konfomasyon nan EED H3K27me3-obligatwa poch la ak anpeche enteraksyon an nan EED ak methyltransferase améliore omolog zeste 2 (EZH2). MAK683 ap sibi faz II klinik pou idantifikasyon an nan aktivite antitumor.

 

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Baj popilè: mak683 cas 1951408-58-4, manifaktire, founise, faktori, achte, nan stock

• On: BMS-986195 CAS 1912445-55-6
• Pwochen: Adavivint CAS 1467013-03-3