ORM-15341 CAS 1297537-33-7

Deskripsyon pwodwi:

Non pwodwi: ORM-15341 CAS NON: 1297537-33-7

Sinonim:

(S) -3-acetyl-N- (1- (3- (3-chloro-4-cyanophenyl) -1H-pirazol-1-il) propan-2-il) -1H-pirazòl-5-karboksamid;

ORM-15341;

(S) -5-acetyl-N- (1- (3- (3-chloro-4-cyanophenyl) -1H-pirazol-1-il) propan-2-il) -1H-pirazòl-3-karboksamid;

Chimik& Pwopriyete fizik:

Aparans: Poud

Egzamen: ≥99.00%

Pwen bouyi: 714,7 ± 60,0 ℃ (prevwa)

Dansite: 1.41 ± 0.1 g / cm3 (prevwa)

Pka: 8.70 ± 0.10 (prevwa)

Solitid: DMSO: ＞ 37 mg / mL

Depo: -20 ℃ Glase

ORM-15341 se yon antagonis ki pisan ak plen pou AR imen (hAR) ak valè IC50 nan 38 nM jan yo montre nan transactivation tès nan AR-HEK293 selil ki estab eksprime plen longè HAR ak yon androjen-reponn luciferase repòtè jene konstwi.IC50 valè: 38 nMTarget: reseptè Androjenin vitro: Nan tès konpetitif AR obligatwa, anpèchman konstan (Ki) valè ORM-15341 te 8 nM. ORM-15341 fonksyone kòm yon antagonist konplè pou tout AR mutant teste yo, ak IC50 nan 25, 51, 700, ak 1160 nM pou wtAR, AR (F876L), AR (T877A), ak AR (W741L).

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Baj popilè: orm-15341 cas 1297537-33-7, manifaktirè, founisè, faktori, achte, nan stock

• On: 2-Amino-5-kloro-2'-fluorobenzophenone CAS 784-38-3
• Pwochen: 5-ACETYL-1H-PYRAZOLE-3-CARBOXYLIC ACID CAS 1297537-45-1