Osimertinib CAS 1421373-65-0

Product Description

Product Name: AZD-9291 ; Osimertinib CAS NO: 1421373-65-0

 

 

Synonyms:

2-Propenamide, N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-;

Osimertinib;

N-(2-{[2-(Dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino}phenyl)acrylamide;

UNII-3C06JJ0Z2O;

Mereletinib;

AZD-9291;

 

 

Chemical & Physical Properties

Appearance : Yellow Solid.

Assay : ≥99.5%

Density:1.2g/cm3

 

 

Osimertinib (previously known as mereletinib or AZD9291; trade name Tagrisso) is a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals – for mutated EGFR cancers.

 

Osimertinib (AZD-9291) is an irreversible and mutant selective EGFR inhibitor with IC50s of 12 and 1 nM against EGFRL858R and EGFRL858R/T790M, respectively.

 

 

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