R428 (BGB324) CAS 1037624-75-1

Deskripsyon pwodwi:

Non pwodwi: R428 (BGB324) CAS NON: 1037624-75-1

Sinonim:

CS-1046;

R428;

1- (6,7-dihydro-5H-benzo [6,7] cyclohepta [1,2-c] piridazin-3-il) -N3- (7- (S) - (pirolidin-1-il) -6 , 7,8,9-tetrahydro-5H-benzo [7] annulene-2-yl) -1H-1,2,4-triazole-3,5-diamine;

Chimik& Pwopriyete fizik:

Aparans: poud jòn

Egzamen: ≥98.0%

Dansite: 1.41 ± 0.1 g / cm3 (prevwa)

Bouyi Point: 799,6 ± 70,0 ℃ (prevwa)

Flash Point: 437.4 ± 35.7 ℃

PKa: 10.34 ± 0.20 (prevwa)

Presyon vapè: 0.0 ± 2.8 mmHg nan 25 ℃

Endèks Refraksyon: 1.768

Dlo solubility: Ensolubl (5.6E-5 g / L) (25 ℃)

R428 (BGB324) se yon inibitè AXL ak yon IC50 nan 14nM e se plis pase 100 fwa plis selektif pou AXL pase pou ABL. Selektivite nan aksyon sou Axchemicalbookl tou konpare ak sa ki sou MER ak Tyro3 (50 a 100 fwa pi wo) ak INSR, EGFR, HER2 ak PDGFRβ (plis pase 100 fwa pi wo). Bemcentinib (R428) se yon inibitè ki pisan ak selektif nan Axl ak yon IC50 nan 14 nM.

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Baj popilè: r428 (bgb324) cas 1037624-75-1, manifaktirè, founisè, faktori, achte, nan stock

• On: (S) -3- {6 - [(tetrahydrofuran-3-yloxy) methyl] piridin-2-ilmetil} -7- (5-methyl-2-furyl) -3H- [1,2,3] triazolo [4 , 5-d] pirimidin-5-ylamin CAS 1202402-40-1
• Pwochen: (R) -6-(2-fluorophenyl) -N-(3-(2-((2-methoxyethyl)amino)ethyl)phenyl) -5,6-dihydrobenzo[h]quinazolin-2-amine CAS 1234356-69-4