TAK-438, Vonopra fumarate CAS 1260141-27-2

Pwodwi Deskripsyon:

Non pwodwi: TAK-438 Vonopra fumarate CAS NON: 1260141-27-2

 

 Sinonim:

1-[5-(2-Fluorophenyl) -1-(3-pyridinsulfonyl) -1H-pyrrol-3-yl] -N-methylmethanamine (2E) -2-butenedioate (1:1);

1-(5-(2-fluorophenyl) -1-(piridin-3-ylsulfonyl) -1H-pyrrol-3-yl) -N-methylmethanam fumarate;

1-[5-(2-fluorophenyl) -1-pyridin-3-ylsulfonylfonylrol-3-yl] -N-methylmethanamine, (E) -4-oksopent-2-asid enosik;

5-(2-Fluorophenyl) -N-methyl-1-(3-pyridinsulfonyl) -1H-pyrrole-3-methanamine (2E) -2-butenedioate;

  

Chimik & Pwopriyete fizik:

Aparans : poud.

Assay: ≥99.0%

Soluble: DMSO > 10 mm

 

Altene CAS #: Gratis Baz: 881681-00-1

 

Tak-438 (vonopra fumarate) se yon nouvo oral anti gastric dwog devlope pa Pranda pharmaceutique ak Otsuka famasetik.

[klasifikasyon enskripsyon] medikaman chimik 3.1

[endikasyon] pou tretman an nan esophagitis eroshagitis, ulse gastric ak ulcer duodenal. Sou fevriye 28, 2014, Pranda pharmaceutique soumet aplikasyon an dwog nouvo (NDA) nan vonopan (tak-438) nan Ministe a nan travay, sante ak byennet nan Japon (MHLW). Soumet la nan aplikasyon an dwog nouvo ki baze sou done yo bon nan faz III ese klinik. Pranda famasetik te pote soti plizye faz III klinik ese klinik nan Japon pou mennen anket sou efikasite nan travay-438 nan eliminasyon an nan esophagitis erozif, ilse gastrik, ulse duodenal ak Helicobacter lapriye. Nan ese klinik, konpare ak PPIs aktyel la, razan liv chimik lage (tak-438) pa gen CYP2C19 du, Se konsa, li montre pi bon efikasite nan ese klinik: li se pi bon pase lansoprazole nan tretman an nan ilse gastrik / ilse duodenal, esophagitis rflu, retire rasin nan elikobacter priyorite, e li gen bon tolerans ak sekirite. Sou Desanm 26, 2014, tak-438 (vonoprafumarate) te apwouve pou maketing nan Japon (non komes: prancab) pou tretman an nan maladi asid ki gen rapo. Konpare ak inibite yo tradisyonel ireversible pwoton (tankou omeprazole, esomeprazole, elatriye), prancab gen avantaj sa yo: (1) rapid onset, premye jou a nan administrasyon ap reyalize efe a maksimom asid; (2) administrasyon oral, pa afekte pa domaj asid gastric, pa bezwen fet nan solisyon dejwe; (3) amelyore fenomen nan asid asid.

 

 

Aplikasyon: Vonoprazan Fumarate se yon blok potasyom-konpetitif aside pou tretman an nan maladi aside-ki gen rapo.

 

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Baj popilè: tak-438, vonopra fumarate cas 1260141-27-27, manifaktire, founise, faktori, achte, nan stock

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