Tofacitinib Sitrat CAS 477600-75-2

Deskripsyon pwodwi:

Non pwodwi: Tofacitinib sitrat CAS NON: 477600-75-2

Sinonim:

(3R, 4R) -4-methyl-3- (methyl-1H-pyrrolo [2,3-d] pyrimidin-4-ylamino) -β-oxo-1-piperidinepropanenitrile;

Tofacitinib;

Tasocitinib;

Chimik& Pwopriyete fizik:

Aparans: poud pal

Egzamen: ≥99.0%

Dansite: 1.296g / cm3

Pwen bouyi: 585.845 ℃ nan 760 mmHg

Flash Point: 308.108 ℃

Refractive Index: 1.646

Presyon vapè: 0.0 ± 1.6 mmHg nan 25 ℃

Enfòmasyon sou sekirite:

HS Kòd: 29335990

Siyal Pawòl: Avètisman

Deklarasyon danje: H315; H319; H335

Deklarasyon Prekosyon:

P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

CP-690550 se yon dérivés pyrrolo [2,3-d] pirimidin, tankou Janus kinase inibitè pou tretman atrit rimatoyid.

Non sistèm chimik sitrat Tofacitinib la se 3 - {(3R, 4R) -4-methyl-3 - [methyl - (7H-pyrronozo [2,3-d] pyrimidine-4-il) -piperidin-1-il] -3-oxo-propionitrile sitrat, Chemicalbook se yon inhibiteur Janus kinase devlope pa Pfizer (USA). 6 novanm 2012, US Food and Drug Administration (FDA) apwouve dwòg la pou tretman adilt ki gen modera a grav aktif atrit rimatoyid (RA) ki gen yon repons apwopriye oswa entolerans nan terapi metotreksat. Tofatib endike pou pasyan granmoun ki gen modera a grav aktif atrit rimatoyid (RA) ki gen mank oswa entolerans repons MTX epi yo ka itilize nan konbinezon ak MTX oswa lòt abiotik amelyore ajan antirumatik (DMARDs).

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