Rifampin: evalyasyon nan itilize li yo nan periprosthetic enfeksyon ki te koze pa staphylococci

Rifampin souvan itilize pou trete enfeksyon periprosthetic (PJI) ki te koze pa staphylococci. Sepandan, si yo sevi ak Rifampin, le yo sevi ak Rifampin, ak ki jan yo sevi ak Rifampin rete yon pwoblem kontwovesyal. Etid la evalye kondisyon pasyan yo trete ak Rifampin epi yo pa trete ak Rifampin, ak analize Efe yo nan Rifampin itilize tan, kantite doz, ak konbinezon ak antibyotik sou kondisyon pasyan an.

Etid la evalye ka nan staphylococcal periprosthetic enfeksyon apre pasyan sibi chiriji debridement soti nan 1999 a 2017, epi swiv moute pou plis pase ane 1. Si pasyan an bezwen nenpot operasyon plis ki gen rapo ak enfeksyon nan, li se yon ka echek tretman; Si pasyan an bezwen retire pwotez yo jwenti pandan peryod la swiv-up, oswa te mouri akoz staphylococcal egi jwenti pwotez enfeksyon, li se yon ka echek klinik.

Etid sa a analize 669 ka pasyan. Pami yo, 32,2% (131/407) nan pasyan trete ak Rifampin echwe, ak 54,2% (142/262) nan pasyan ki abandonnées Rifampin echwe (P<0.001). rifampin="" has="" the="" most="" significant="" effect="" in="" the="" knee="" joint,="" 28.6%="" of="" the="" failure="" cases="" of="" rifampin="" were="" used,="" and="" 63.9%="" of="" the="" unused="" group="" (p=""><0.001). multivariate="" analysis="" found="" that="" the="" use="" of="" rifampin="" was="" an="" independent="" predictor="" of="" treatment="" success="" (or="" 0.30,="" 95%="" ci="" 0.20-0.45).="" in="" the="" rifampin="" treatment="" group,="" combined="" antibiotics="" other="" than="" fluoroquinolone="" or="" clindamycin="" were="" used="" (or="" 10.1,="" 95%="" ci="" 5.65-18.2)="" and="" rifampin="" was="" started="" within="" 5="" days="" after="" surgical="" debridement="" (or="" 1.96,="" 95%="" ci="" 1.08-3.65)="" is="" a="" predictor="" of="" treatment="" failure.="" in="" addition,="" the="" dose="" of="" rifampin="" did="" not="" have="" a="" significant="" effect="" on="" the="">

Figi tretman echek (a) ak echek klinik (B) ka ak oswa san Rifampin

An konklizyon, etid la kwe ke Rifampin yo ta dwe itilize nan ka ta gen enfeksyon prosthesis jwenti ki te koze pa staphylococcus apre debridement chiriji, espesyalman nan ka jenou prosthesis enfeksyon. Sepandan, Rifampin pa ta dwe itilize imedyatman apre debridement chiriji, ak itilize nan Rifampin bezwen plis etid.